| abstract |
The present invention relates, among other things, to self-buffering protein formulations. In particular, the present invention provides self-buffering pharmaceutical protein formulations suitable for veterinary and human medical use. The self-buffering protein formulations of the present invention are substantially free of other buffers and maintain a stable pH for extended periods of time involving the distribution and storage of pharmaceutical proteins suitable for veterinary and human medical use. The invention also provides methods of planning, preparing, and using the formulations. In addition to other advantages, the formulations of the present invention avoid the disadvantages associated with buffers commonly used in current protein formulations for pharmaceutical use. The present invention in these and other embodiments can be applied to a variety of proteins in various ways, and particularly useful in the preparation and use of self-buffering formulations of pharmaceutical proteins suitable for veterinary use and medical use, human experiments. It is particularly useful for treating a disease in a subject. |