| abstract |
The present invention relates to a nanoparticle composition comprising a camptothecin derivative, a solid polyethylene glycol, and an association agent, and a method for preparing the same, wherein the camptothecin derivative, which is poorly water-soluble according to the present invention, is solidly dispersed in polyethylene glycol and includes an association agent. By preparing a composition comprising nanoparticles of camptothecin derivatives dissolved in an aqueous solution, the lactone form of the camptothecin derivatives can be stably maintained in body fluids, thereby exhibiting effective anticancer activity. |