| abstract |
The present invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and are represented by Formula I:n n n Formula In n n n n n n n Wherein Spiro-piperidine head group A and residues R 1 , R 2 and R 3 are as defined herein.n n n The invention also relates to pharmaceutical compositions containing such compounds; Their use in medicine for menstrual distress, hypertension, chronic heart disease, inappropriate secretion of vasopressin, cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety disorder and depressive disorder; And methods for their preparation. |