| abstract |
The present invention provides novel substituted tetracyclics having binding affinity for serotonin receptors, in particular 5-HT 2A and 5-HT 2C receptors, and dopamine receptors, especially dopamine D 2 receptors, and having noepinephrine reuptake inhibition properties. Tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives, pharmaceutical compositions comprising the compounds of the invention, their use as medicaments, in particular of various psychiatric and neurological disorders, in particular of certain psychiatric disorders, cardiovascular diseases and gastric dyskinesia It relates to the use thereof for the prophylaxis and / or treatment and a method of making the same. The compounds of the present invention may be represented by general formula (I) and also include pharmaceutically acceptable acid addition salts or base addition salts, stereochemically isomeric forms, N-oxide forms and prodrugs, all substituents of claim 1 As defined in. |