| abstract |
The present invention relates to inhibitors of nitric oxide synthase (NOS) 5 inhibitors, particularly nitric oxide synthase, which selectively inhibits neuronal nitric oxide synthase (nNOS) over other NOS isoforms. NOS inhibitors of the invention can be used alone or in other pharmaceuticaln n n By combination with poorly active agents, for example, seizures, reperfusion injury, neurodegeneration, head trauma, CABG, migraine with or without aura, allodynia To treat conditions such as migraine, central seizure pain (CPSP), neuropathic pain, morphine / opioid-induced tolerance and hyperalgesia Can be used to prevent.n n n n Nitric oxide synthase, indole compounds, inhibitors, neurons |