| abstract |
A compound of formula (I) or a pharmaceutically acceptable salt thereof, allergic-induced airway response, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic fatty liver, using the compound alone or in combination with other agents, Compositions and methods are described for treating cirrhosis, hepatocellular carcinoma and cognitive deficiency diseases.n n n Formula In n n n n n n n In Formula I,n n n M 1 and M 3 are CH or N;n n n M 2 is CH, CF or N;n n n Y is —C (═O) —, —C (═S) —, — (CH 2 ) q —, —C (═NOR 7 ) — or —SO 1 — 2 —;n n n Z is a bond or optionally substituted alkylene or alkenylene;n n n R 1 is H or both optionally substituted alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, or a group of formula II;n n n Formula IIn n n n n n n n In Chemical Formula II,n n n Ring A is a heteroaryl ring;n n n R 2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl;n n n R 3 is H, —C (O) NH 2 or all are optionally substituted alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl;n n n The remaining variables are as defined in the specification. |