abstract |
The present invention relates to novel indole carboxamide derivatives. In particular, the present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts thereof. The compounds of the present invention are IKK2 inhibitors and may be useful for the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the present invention also relates to pharmaceutical compositions comprising the compounds of the present invention. The invention also relates to a method of inhibiting IKK2 activity using a compound of the invention or a pharmaceutical composition comprising a compound of the invention and to a method of treating a disorder associated with IKK2 activity.n n n <Formula I>n n n n n n n n Wherein R 1, R 2, R 3, U and V are defined herein. |