| abstract |
The present invention provides novel selective estrogen receptor modulator compounds of general formula (I) and their nontoxic pharmacologically acceptable salts, esters and mixtures thereof, which compounds exhibit important pharmacological properties :n n n n n n n n Wherein R 1 and R 2 are the same or different and comprise a) H, halogen, OCH 3 or OH; Or b) a compound of formula (II); Or c) -Y- (CH 2 ) nCH 2 -O-R6; Or d) 2,3-dihydroxypropoxy, 2-methylsulfamyethoxy, 2-chloroethoxy, 1-ethyl-2-hydroxyethoxy, 2,2-diethyl-2-hydroxy Oxy or carboxymethoxy; And R 3 is H, halogen, OH or —OCH 3 . In the compound of formula (II) X is O, NH or S; n is an integer from 1 to 4; R 4 and R 5 are the same or different and are 1 to 4 carbon alkyl, H, —CH 2 C≡CH or —CH 2 CH 2 OH; Or R 4 and R 5 are N-containing 5- or 6-membered rings or heteroaromatic rings. Y is O, NH or S in —Y— (CH 2 ) nCH 2 —O—R 6; n is an integer from 1 to 4; R6 is H, -CH 2 CH 2 OH or -CH 2 CH 2 Cl. |