| abstract |
The present invention relates to a quinazoline derivative of formula (I) and a process for its preparation, a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a pharmaceutical composition containing the same and a use as a therapeutic agent. The present invention relates to a quinazoline derivative having a phosphodiesterase V (PDE 5) inhibitory activity.n n n n n n n n R 1 , R 2 , R 3 , R a , R b and R c in the formula (I) are as defined in the detailed description of the invention, respectively. The compound of the formula is excellent in selectively inhibiting phosphodiesterase V (PDE V), and thus useful as a therapeutic agent in cardiovascular diseases such as male erectile dysfunction, angina pectoris, hypertension, pulmonary pulmonary hypertension and atherosclerosis. Can be used. |