| abstract |
The present invention relates to novel tetracyclic tetrahydrofuran derivatives containing cyclic amine side chains having binding affinity for serotonin receptors, in particular 5-HT2A and 5-HT2C receptors and dopamine receptors, in particular dopamine D2 receptors. A pharmaceutical composition comprising the compound according to the present invention, in particular as a medicament, relates to a range of psychiatric and neurological disorders, in particular for use in the prevention and / or treatment of certain psychotic, cardiovascular and gastric motor movement disorders and methods for their preparation will be. The compounds according to the invention can be represented by general formula (I) and also comprise their pharmaceutically acceptable acid or base addition salts, their stereochemical isomers, their N-oxide forms and their quaternary ammonium salts , Wherein all substituents are defined in claim 1. |