| abstract |
The present invention relates to novel substituted steroid derivatives which represent selective inhibitors of 17β-hydroxysteroid dehydrogenase type I (17β-HSD1) and which may also represent inhibitors of said steroid sulfatase, , Their salts, pharmacological preparations comprising these compounds and processes for preparing these compounds. The present invention also relates to the therapeutic use of such new substituted steroid derivatives, in particular requiring inhibition of 17β-hydroxysteroid dehydrogenase type I and / or inhibition of steroid sulfatase enzymes, and And / or the use of such compounds in the treatment or prevention of steroid hormone dependent diseases or disorders such as steroid hormone dependent diseases or disorders requiring lowering endogenous 17β-estradiol concentrations. |