| abstract |
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, solvate or stereoisomer thereof:n n n n n n n n {Wherein: R 1 is a group selected from -CH 2 OH, -NHC (O) H, R 2 is a hydrogen atom; Or R 1 , together with R 2 , is bonded to a carbon atom in a phenyl ring having a nitrogen atom of R 1 and a carbon atom in a phenyl ring having a carbon atom of R 2 —NH—C (O) —CH═CH— To form a group; R 3 is hydrogen and halogen atom, or -SO-R 5 , -SO 2 -R 5 , -NH-CO-NH 2 , -CO-NH 2 , hydantoino, C 1-4 alkyl, C 1-4 alkoxy and —SO 2 NR 5 R 6 ; R 4 is selected from a hydrogen atom, a halogen atom and a C 1-4 alkyl group; R 5 is a C 1-4 alkyl group or C 3-8 cycloalkyl; R 6 is independently selected from a hydrogen atom and a C 1-4 alkyl group; n, p and q are independently 0, 1, 2, 3 or 4; m and s are independently 0, 1, 2 or 3; r is 0, 1 or 2; Provided that at least one of m and r is not zero; The sum n + m + p + q + r + s is 7, 8, 9, 10, 11, 12 or 13; The sum q + r + s is 2, 3, 4, 5 or 6}. |