| abstract |
The present invention relates to purine derivatives, methods for their preparation, compositions containing them and their use. The present invention provides compounds of formula (I)n n n <Formula I>n n n n n n n n Wherein R 1 , R 2 , R 3 , R 9 , R 9a and Y are as defined in the specification. More specifically, the present invention relates to the use of purine derivatives in the treatment of various viral infections and immune or inflammatory disorders, including the regulation of toll-like receptors (TLRs), in particular disorders associated with agonism. Accordingly, the compounds of the present invention are useful for the treatment of infectious diseases such as hepatitis (eg HCV, HBV), genetically related viral infections, inflammatory diseases such as asthma and arthritis, and cancer. |