http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20080005926-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2006-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ffd155fe0520701b45ae824d60372b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4445ead7cc643ec15b53439462913dc0 |
| publicationDate | 2008-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20080005926-A |
| titleOfInvention | Biomarkers on the Efficacy of Aliskiren as an Antihypertensive Agent |
| abstract | Retrospective pharmacogenetic analysis was performed to evaluate the potential association between clinical trial results and genetic changes in the efficacy of aliskiren as an antihypertensive agent. 48 polymorphisms from 12 genes previously associated with the Lenin-Angiotensin-Aldosterone System (RAS) or previously in blood pressure control were tested. There was a significant association between one polymorphism of the angiotensin converting enzyme (ACE) gene, two polymorphisms of the angiotensin II type 2 receptor (AGTR2) gene, and clinical parameters of mean loci diastolic and systolic blood pressure reduction. This effect was not observed in irbesartan and placebo treatments but was specific to aliskiren treatment. |
| priorityDate | 2005-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 218.