| abstract |
An object of the present invention is to provide a pharmaceutical composition containing a proton pump inhibitor and which is stable even after long-term storage. Another object of the present invention is to provide a pharmaceutical composition which contains a proton pump inhibitor which is weak in acid, does not dissolve in the stomach, dissolves in the intestine, and rapidly releases the main medicine. According to the present invention, a pharmacologically inert nuclear material is coated with a layer containing a proton pump inhibitor and ethyl cellulose and a layer containing an enteric polymer, and, if necessary, one or more intermediate layers are further coated. By providing the pharmaceutical composition characterized by the above-mentioned, the objective mentioned above can be achieved. The intermediate layer is composed of a water-insoluble polymer, a water-soluble polymer, a lubricant. |