| abstract |
Nanoparticulate compositions comprising corticosteroids and leukotriene receptor antagonists are described. The composition is useful for the prevention and chronic treatment of asthma in adult and pediatric patients, and for the alleviation of symptoms of allergic conjunctivitis and seasonal allergic rhinitis in adults and small eye patients. Combining corticosteroids with leukotriene receptor antagonists in a particle size range of less than about 2000 nm in a single formulation improves efficacy. In addition, since only a single dosage form is required, patient compliance is improved. In addition, topical administration of leukotriene receptor antagonists results in less hepatotoxicity because the liver will be exposed to lesser amounts of drug than occurs after oral administration. Drug compositions according to the invention may be formulated as inhalation, nasal, or ocular preparations. |