| abstract |
The present invention provides pyrimidine derivatives of the general formula (I) and pharmaceutically acceptable salts thereof and hydrolyzable esters in vivo. The present invention also provides methods for its preparation, pharmaceutical compositions, and their use as cyclin dependent serine / threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors:n n n n Formula In n n n n n n n n Wherein Q 1 , Q 2 , G and R 1 are as defined in the specification. |