| abstract |
Heterocyclic-substituted tricyclics of Formula (I), or pharmaceutically acceptable salts or solvates, isomers or racemic mixtures of the compounds, as well as pharmaceutical compositions containing them, and thrombosis by administering the compounds, Methods are described for treating diseases associated with atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure and cancer:n n n [Formula I]n n n n n n n n In Formula I,n n n Represents any double bond,n n n The dashed line is optionally a bond or not a bond, creating a double bond or a single bond as allowed by valence requirements,n n n A, G, M, X, J, n, Het, R 3 , R 10 , R 11 , R 32 and R 33 are as defined herein,n n n The remaining substituents are as defined herein. Combination therapy with other cardiovascular agents is also claimed. |