| abstract |
General formulan n n n n n n n "In formula, R < 1> is a hydrogen atom or a carboxyl protecting group; R 2 is phenyl which may be substituted or a heterocyclic group; R 3 is phenyl which may be substituted or a monocyclic heterocyclic group or the like; X 1 is a carbonyl group or the like; X 2 is an alkylene group which may be substituted or the number of bonds; X 3 is an oxygen atom or a bond water; And the like "wherein, X 5 is an oxygen atom or X 4 is a bond, the formula, -X 5 -X 6 - - or -X 6 -X 5; X 6 means an alkylene group which may be substituted or the number of bonds and the like. ”Represents a group represented by.” Since the anthranilic acid derivative or salt thereof has an MMP-13 production inhibitory effect, It is useful as a therapeutic agent for arthritis rheumatoid, deformable arthrosis and cancer. |