| abstract |
The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In certain embodiments, the present invention provides a fully human, humanized or chimeric anti-IGF-1R antibody, an IGF-1R binding fragment, a derivative of the antibody and an IGF-1R binding poly comprising said fragment which binds to human IGF-1R. Provide peptides. In another aspect, the present invention provides the antibody, antibody fragment, derivative, nucleic acid encoding a polypeptide, cells comprising such polynucleotides, methods of preparing said antibody, antibody fragment, derivative and polypeptide, said antibody, antibody fragment, Methods of using derivatives and polypeptides, such as methods of treating or diagnosing a subject having an IGF-1R related disorder or condition. |