| abstract |
The present invention provides novel substituted heterocyclics having binding affinity for serotonin receptors, in particular 5-HT 2A and 5-HT 2C receptors, and dopamine receptors, especially dopamine D 2 receptors, and having noepinephrine reuptake inhibition properties. Tetracyclic tetrahydrofuran derivatives, pharmaceutical compositions comprising the compounds of the invention, their use as medicaments, in particular for the prevention and / or treatment of various psychiatric and neurological diseases, in particular certain psychiatric disorders, cardiovascular diseases and gastrointestinal disorders It relates to the use thereof and a method for producing the same. The compounds of the present invention may be represented by general formula (I), and also all substituents thereof are pharmaceutically acceptable acid addition salts or base addition salts, stereochemical isomers, N-oxide forms and pros as defined in claim 1. Contains a drag. |