| abstract |
The present invention provides compounds of formula (I), or salts, tautomers, solvates and N-oxides thereof.n n n <Formula I>n n n n n n n n In the formula,n n n R 1 isn n n (a) 2,6-dichlorophenyl;n n n (b) 2,6-difluorophenyl;n n n (c) a 2,3,6-trisubstituted phenyl group, wherein the substituent for the phenyl group is selected from fluorine, chlorine, methyl and methoxy; Andn n n (d) R 0 group (wherein, R 0 is a carbocyclic or heterocyclic group of 3-to 12 members; or a C 1 -8 hydrocarbyl bilim optionally substituted) is selected from;n n n R 2a and R 2b are each hydrogen or methyl;n n n R 3 is as defined in the claims.n n n The compound is active as an inhibitor of cyclin dependent kinase (CDK) and glycogen synthase kinase (GSK) kinase and is useful for the treatment or prevention of disease states or symptoms mediated by the kinase. |