| abstract |
The present invention provides antibiotics of microbial origin (optionally designated as antibiotic 107891) produced by fermentation of Microbispora species ATCC PTA-5024, pharmaceutically acceptable salts and compositions thereof, and inhibitory activity against susceptible microorganisms. It relates to their use as an antimicrobial agent. Antibiotic 107891, a complex comprising two factors (named Factors A1 and A2), has a peptide structure containing lanthionine and methyllanthionine as components, typical of antibiotics of the lantibiotic group. Antibiotics 107891 and its factors A1 and A2 show good antimicrobial activity against Gram-positive bacteria, including methicillin resistant and vancomycin resistant strains, and some Gram-negative bacteria such as M. a. M. catharralis, Neisseria spp. And H. It is also active against influenzae (H. influenzae) and mycobacteria (Mycobacteria). |