| abstract |
The present invention relates to a Grb7 fusion protein that can be easily penetrated into the dermis or into a cell when applied to the skin surface by forming a Grb7 fusion protein in which the Grb7 protein and the protein transport domain are covalently bound, and more specifically, Protein transport domain is composed of 15 to 30 amino acids, hydrophobic domain containing 5 or more tryptophan (hydrophobic domain), hydrophilic domain containing a large number of lysine (spacer) separating the two domains (spacer) ), And the concentration-dependent, time-dependent penetration into the cells smoothly compared to the control, and lasted more than 48 hours in the cells. |