The present invention relates to the number of ring atoms in which R 1 , R 3 , V 1 , V 2 , X 1 , X 2 , Y, Z, Ar, AA and n are as defined herein and are included in a macrocyclic ring Nos. 14, 15, 16, 17 or 18, in the free base form or in the acid addition salt form, novel macrocyclic compounds of the formula (I), methods for their preparation, their use as medicaments and medicaments comprising them.n n n <Formula I>