| abstract |
Derivatives having a strong and broad antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria including various resistant bacteria, and novel analogs of mutilin, which are expected to be used as therapeutic agents for infectious diseases, and substituted at position 12 represented by the following compound (1) And intermediates thereof.n n n [Compound (1)]n n n n n n n n (In formula, R < 1> represents a hydrogen atom, a formyl group, a lower alkyl group, etc., and R < 2> represents a hydrogen atom, a lower alkyl group, etc., except the case where R < 1> is an ethyl group or a vinyl group.) |