| abstract |
Compound of Formula (I):n n n Wherein Z is -N- or>CH; R 1 is -H or -C 1 - 4 alkyl; Ar 1 is 2-thiazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, or phenyl, each of which has a carbon reduction Unsubstituted or substituted with one or two R a moieties; Wherein each R a portion of -C 1 - 4 alkyl, -C 2 - 4 alkenyl, -OH, -OC 1-4 alkyl, halo, -CF 3, -OCF 3, -SCF 3, -SH , -S (O) 0-2 C 1 - 4 alkyl, -OSO 2 C 1 - 4 alkyl, -CO 2 C 1 -4 alkyl, -CO 2 H, -COC 1 - 4 alkyl, -N (R b ) R c , -SO 2 NR b R c , -NR b SO 2 R c , -C (= 0) NR b R c , -NO 2 , and -CN are independently selected from the group consisting of b and R c are each independently -H or -C 1 - 4 alkyl and; Ar 2 as defined in the claims is useful as a FAAH inhibitor. Such compounds can be used in pharmaceutical compositions and methods for treating conditions, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds can be administered to treat, for example, anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (eg multiple sclerosis). |