| abstract |
The pharmaceutical composition of the present invention comprises (1) carbostyryl derivative and (2) serotonin reuptake inhibitor in a pharmaceutically acceptable carrier. The carbostyryl derivative may be aripiprazole or a metabolite thereof, which is a dopamine-serotonin system stabilizer. Serotonin reuptake inhibitors can be fluoxetine, duloxetine, venlafaxine, milnacipran, citalopram, fluvoxamine, paroxetine, sertraline, escitalopram. The pharmaceutical compositions of the invention are useful for treating patients with mood disorders, in particular depression or major depressive disorder. |