| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c4322cb4de342be2dbedcbe0c278f6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ecd03acca85bf5758dc77fd44739c9bb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-96 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0012
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-96 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-96 |
| filingDate |
2001-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba8d59fb7b818de1ff69c1db83a8f568
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d38fc927831eb7666f978cea0884f022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a54cb7ed697574bb21f9d8c002c7d00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c616b2ed319fee8cacef52246785419
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94868035aad30ffa5bc6956a4f82f3bd |
| publicationDate |
2007-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20070092329-A |
| titleOfInvention |
Aggregate-free urate oxidase for the preparation of non-immunogenic polymer conjugates |
| abstract |
Naturally occurring or recombinant proteins that are essentially free of large aggregates, particularly muteins (mutants) of porcine uric acid oxidase (uricase), may be used in the polymer so that the bioactivity of the protein remains essentially within the conjugate. Conjugation with a sufficiently small number of strands can result in substantially non-immunogenicity. Such conjugates are particularly well suited for the treatment of chronic symptoms because they cause less antibody formation and / or accelerated clearance than similar conjugates prepared from protein preparations containing trace amounts of large aggregates. same. |
| priorityDate |
2000-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |