| abstract |
The present invention relates to substituted triazolone, tetrazolone and imidazolone derivatives according to the general formula (I) pharmaceutically acceptable acid or base addition salts thereof, stereochemical isomers thereof, N-oxide forms thereof or quaternary ammonium salts thereof. Wherein the variable is defined in claim 1 and has selective α 2C -adrenoreceptor antagonist activity. In addition, it relates to the preparation thereof, compositions comprising the same and their use as medicaments. The compound according to the present invention is a central nervous system disease, mood disorders, anxiety disorders, stress-related disorders associated with depression and / or anxiety, cognitive disorders, personality disorders, schizophrenic disorders, Parkinson's disease, Alzheimer's dementia, chronic pain states, nerves It is useful for the prevention and / or treatment of degenerative diseases, addiction diseases, mood disorders and sexual dysfunctions. |