| abstract |
expressionn n n n n n n n In the formula,n n n R 1 represents a hydrogen atom, a lower alkyl group, an amino group, a halogen atom, a lower alkoxy group, and the like.n n n R 2 represents a substituted or unsubstituted aryl group, and the like.n n n R 3 represents a hydrogen atom or a lower alkyl group,n n n R 4 represents a substituted or unsubstituted phenyl group, and the like,n n n Y represents -CH 2- , -CO-, -CH (CH 3 )-, -O-, -NH- and the like.n n n An isoxazole derivative having a superior P38MAP kinase inhibitory activity, or a pharmaceutically acceptable salt thereof, is disclosed. |