| abstract |
A water soluble structure comprising the structure POLY- [YSW] x, wherein POLY is a water-soluble polymer; Y is a hydrocarbon-based spacer group, x is from 1 to 25, and SW is a thiol, a protective thiol, or a thiol-reactive derivative Polymeric reagents are disclosed. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are conjugates of the polymeric reagents with pharmaceutically corresponding molecules, and methods for their formation and use. |