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publicationDate 2007-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20070088695-A
titleOfInvention Separation Method of Fulvestrant Isomers
abstract The present invention comprises the steps of injecting a fulvestrant sample into HPLC using a reversed phase column or chiral column; Eluting the sample with an eluent comprising a first mobile phase and a second mobile phase; And collecting a purified fraction of fulvestrant sulfoxide A or fulvestrant sulfoxide B from the column. The method provides fulvestrant sulfoxide A or fulvestrant sulfoxide B having a purity of 99.5% as determined by HPLC.
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