| abstract |
The present invention is a human antithrombin variant with high protease inhibitory activity even in the absence of heparin, wherein one or more of amino acids at positions 78, 278, 378 and 380 of the amino acid sequence of natural human antithrombin are converted to other amino acids. Provide human antithrombin variants. Preferably at position 78 by Phe; Position 278 is selected by Ala, Arg, Asn, Gly, His, Tyr or Val; 378 position by Lys, Asn or Val; And / or human antithrombin variants wherein the 380 position is converted by Ala, Asp, Gly, His, Ile, Leu, Asn, Pro, Arg, Thr, Tyr or Val. |