| abstract |
N- [1S, 2S] -3-[(4-chlorophenyl) -2- (3-cyanophenyl) -1-methylpropyl] -2-methyl-2-{[(5-trifluoromethyl) Pyridin-2-yl] oxy} propanamide (Compound I) is a solubility and biomaterial in a lipophilic vehicle comprising a pharmaceutically acceptable extinguishing oil, surfactant, or cosolvent, or any two or more mixtures thereof. The utilization rate is surprisingly improved. One aspect of the present invention provides a composition comprising: 1) Compound I; 2) surfactants with HLB from 1 to 8; And 3) surfactants having an HLB of at least 8 to 20; And optionally 4) an auto emulsifying or auto microemulsifying composition comprising a extinguishing oil and / or cosolvent and / or an oxidizing agent or preservative. |