| abstract |
The present invention ensures the bioavailability (BA) of a drug containing a bioactive peptide or a bioactive protein containing ghrelins as an active ingredient, a more effective liquid formulation; A method for improving BA by subcutaneous injection of an aqueous solution containing ghrelins and the like; A method of improving BA upon subcutaneous injection of an aqueous solution in which ghrelin is dissolved; 1 or 2 selected from the group consisting of acetic acid, lactic acid, phosphoric acid, glycine, citric acid, hydrochloric acid, pyrionic acid, butyric acid, benzoic acid, or salts thereof as the active ingredient comprising ghrelins Acidic solution containing at least one combination as a component, and / or one or two or more combinations selected from the group consisting of alcohols, N-methyl-2-pyrrolidone, dimethylformamide, dimethyl sulfoxide and methylparaben It provides a liquid formulation comprising a polar organic liquid containing as a component. |