http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20070054953-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_717c792fca7cc9c290c9db33e8fe078b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-708 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-708 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2005-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93d87e54eb8ab1a60fc5043f89091b43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaf6cf0b72a9d268195ef60390357f3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50eb099b7dfec0050ce1772c81a7ac11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a96eff6877ee6191ac0c7fcddf3a510 |
| publicationDate | 2007-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20070054953-A |
| titleOfInvention | Anti-inflammatory composition |
| abstract | The present invention is an anti-inflammatory composition containing at least one component of 8-oxo-guanosine (oh8G) and 8-oxo-deoxyguanosine (8-oxo-deoxyguanosine, oh8dG) as an active ingredient. To provide.n n n The composition containing one or more components of the oh8G, oh8dG of the present invention as an active ingredient inhibits the activity of Rac2 of macrophages, and also inhibits the activity of NADPH oxidase and at the same time inhibits the production of free radicals.n n n In addition, the composition of the present invention significantly inhibits the increase in blood concentration of LPS-induced pro-inflammatory cytokine, inhibits the increase of myeloperoxidase (MPO) activity in lung tissue, inhibits the increase of Rac2 activity in lung tissue, and mouse mortality rate by LPS. Suppressn n n Therefore, the anti-inflammatory composition of the present invention can be usefully used as an anti-inflammatory agent against various inflammatory diseases such as rheumatoid arthritis, lupus erythematosus, multiple scleroderma, adult respiratory distress syndrome. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200137935-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200145656-A |
| priorityDate | 2005-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.