| abstract |
A compound of formula [I] or a prodrug or salt thereof:n n n n n n n n Wherein -Y-, R 4 , R 5 and R 6 are as defined in the detailed description of the invention,n n n R 1 is hydrogen, halogen, lower alkyl, hydroxy, and the like,n n n R 2 is hydrogen, lower alkyl or hydroxy (lower) alkyl,n n n R 3 is hydrogen or an amino protecting group,n n n R 7 is hydrogen, lower alkyl, cyclo (lower) alkyl, lower alkenyl, —ZR 9 or Wherein -Z- is -O-, -S-, -SO- or -SO 2- ,n n n Each R 9 is independently hydrogen, lower alkyl, cyclo (lower) alkyl, and the like,n n n R 8 is -DER 10 , wherein -D- is -CONHSO 2 -or -SO 2 NHCO-,n n n E is a bond or lower alkylene,n n n R 10 is halogen, cyano, carboxy and the like.n n n Compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and / or therapeutic treatment of ulcers, bladder hyperactivity, and the like. |