| abstract |
The present invention relates to the production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Thus, in one aspect, the present invention provides 17-desmethylrapamycin and its analogs, their production methods including recombinant strains, and the isolation and use of the compounds of the present invention. In another embodiment, the present invention provides for the induction or maintenance of immunosuppression, the promotion of neuronal regeneration or cancer, B-cell malignancies, fungal infections, transplant rejection, graft-versus-host disease, autoimmune diseases, inflammatory diseases, Provided is the use of 17-desmethylrapamycin and its analogues in the treatment of vascular disease or fibrosis or in the treatment of wounds.n n n n Rapamycin, polyketides, 17-desmethylrapamycin |