abstract |
The present invention relates to nublastin polypeptides substituted with selected amino acid residues. Modified nublastin polypeptides substituted for one or more selected amino acids reduced heparin binding and increased serum exposure. The present invention also relates to methods of using the modified nublastin polypeptides for treating diseases of mammals and for activating the RET receptor.n n n n Nublastin, nervous system, polypeptide, RET receptor |