| abstract |
Formula (Ⅰ):n n n n n n n n In the formula, preferably, R 1 is a cyclohexyl group, a cycloheptyl group, or a tetrahydropyranyl group, and R 2 Is a methyl group, R 3 Is a hydrogen atom, R 4 is a group: -CONR 5 R 6 A thienopyrazole derivative represented by (wherein either R 5 and R 6 is a hydrogen atom), and has a function of selectively inhibiting PDE7, thereby increasing intracellular cAMP level, furthermore, T cell By inhibiting activation, it is useful for the prevention and treatment of various allergic diseases, inflammatory and immune diseases.n n n Thienopyrazole derivatives, immune diseases |