| abstract |
The present invention relates to novel therapeutically useful novel pyridazin-3 (2H) -one derivatives, methods for their preparation and pharmaceutical compositions containing them. These compounds are potent and selective phosphodiesterase 4 (PDE4) inhibitors and, therefore, the treatment, prevention of pathological conditions, diseases and disorders, especially asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis or irritable bowel disease Or useful for inhibition. |