http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20070032371-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
| filingDate | 2001-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20070032371-A |
| titleOfInvention | Hepatocyte lineage cells derived from pluripotent stem cells |
| abstract | When pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, it has been found that a population of cells with a significantly higher proportion of cells with a phenotype characteristic for hepatocytes is induced. In one example, human embryonic stem cells are formed with embryoid bodies and then combined with the differentiation agent n-butyrate, optionally supplemented with maturation factors. In another example, n-butyrate is added to human embryonic stem cells in culture without feeder cells. In any way, a significantly uniform population of cells is obtained, which express surface markers characteristic of hepatocytes and are predominant in cells with enzymes and biosynthetic activity important for liver function. Stem cells easily proliferate in culture, so the system provides a rich source of hepatocyte lineage cells for supplementation of liver function associated with various applications, such as drug screening and clinical treatment.n n n n Pluripotent Stem Cells, Hepatocytes, n-Butyrate |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20170019883-A |
| priorityDate | 2000-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1538.