http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20070032272-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-02 |
| filingDate | 2004-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20070032272-A |
| titleOfInvention | Oil-based pharmaceutical and cosmetic foams |
| abstract | The present invention provides a stable, oily foam-forming composition comprising at least one active agent for skin and mucosal applications. The composition is well formulated as a foam that provides a stable product that spreads easily and causes high compliance to patients. A "oily" composition has the sensory water-soluble properties of an oily substance, ie an oily feel when topically applied to skin or mucosal tissue.n n n According to one aspect of the invention, the composition comprises:n n n a. A solvent present at a concentration of about 70-96.5% of the total weight of the composition selected from the group consisting of hydrophobic solvents, cosolvents, and mixtures thereof.n n n b. Surfactant at a concentration of about 0.1 to 10% of the total weight of the composition.n n n c. Optionally, a gelling agent at a concentration of about 0.1 to 5% of the total weight of the composition.n n n d. Active agent in a therapeutically effective concentration; Andn n n e. Propellant at a concentration of about 3-25% of the total weight of the composition.n n n Although the composition may be essentially free of lower alkyl alcohols, water and optional ingredients are added to bring the total weight to 100%. In one or more embodiments, the oily compositions of the present invention contain less than about 5% of short chain alcohols having 5 carbon atoms in the carbon skeleton.n n n In one or more embodiments, the oily composition contains water at a concentration of about 30% or less. More preferably about 20% or less, even more preferably about 10% or less by weight.n n n In at least one embodiment, the oily compositions of the present invention further contain a foaming aid.n n n However, in another embodiment, the oily compositions of the present invention form a water-in-oil emulsion.n n n In at least one embodiment, the oily compositions of the present invention comprise a hydrophobic solvent having a solubility of at least about 1 gram per 100 mL in distilled water at ambient temperature. Hydrophobic solvents can be mineral oil, MCT oil, triglyceride oil, polyunsaturated oil, essential oil and mixtures thereof.n n n In at least one embodiment, the oily composition comprises a cosolvent. In at least one embodiment, the cosolvent is a polyol. In at least one embodiment, the cosolvent is a polyethylene glycol derivative, or glycerin. In at least one embodiment, the oily composition of the present invention comprises a mixture of at least one hydrophobic solvent and at least one cosolvent. The mixture of at least one hydrophobic solvent and at least one cosolvent may have a weight ratio of about 1: 8 to 8: 1. In at least one embodiment, a mixture of at least one hydrophobic solvent and glycerin is used; And the mixture may have a weight ratio of about 1: 4 to 4: 1 or about 1: 2 to 2: 1.n n n In one or more embodiments, the oily composition contains at least one solvent having high solubilizing capacity, herein defined as a potent solvent. In the context of the present invention, a strong solvent is a solvent that is not a mineral oil and better than a hydrocarbon solvent, such as mineral oil or petrolatum, for example five times more than mineral oil or ten times more than mineral oil. Are usually solvents that solubilize certain active agents.n n n In at least one embodiment, the oily composition of the present invention is a polyol, polyethylene glycol, propylene glycol, hexylene glycol, butanediols and isomers thereof, glycerol , Benzyl alcohol, dimethyl solfoxide (DMSO), ethyl oleate, ethyl caprylate, diisopropyl adipate, dimethylacetamide, N-methylpyrroli N-methylpyrrolidone, N-hydroxyethylpyrrolidone, polyvinylpyrrolidone, isosorbide derivatives, dimethyl isosorbide, glycofurol and ethoxydiglycol (ethoxydiglycol, transcutol) and a strong solvent selected from the group consisting of any proportion thereof.n n n In at least one embodiment, the oily composition is at least one gelling agent selected from the group comprising natural polymeric materials, semi-synthetic polymeric materials, synthetic polymeric materials, inorganic gelling agents and mixtures thereof It includes. However, in further embodiments, no gelling agent is necessary.n n n The oily compositions of the invention extruded in a pressurized vessel have a specific gravity of about 0.02 gr / mL to 0.5 gr / mL. And treatment for alleviating or preventing dermatological or mucosal disorders.n n n According to a further aspect of the present invention, an oil-in-water emulsion is provided. The emulsion may be essentially free of short chain alcohols. Emulsions include:n n n a. A solvent containing at least one solvent selected from the group comprising hydrophobic solvents, co-solvents and emollients at a concentration of about 30 to 96.5% by weight.n n n b. water;n n n c. At least one nonionic lipophilic surfactant at a concentration of less than about 0.1 to 10% by weight having an HLB value of about 3 to 10;n n n d. Optionally, at least one gelling agent at a concentration of about 0.1 to 5% by weight.n n n e. At least one active agent in a therapeutically effective concentration; Andn n n f. At least one liquefied or compressed gas propellant at a concentration of about 3-25% of the total composition weight.n n n In at least one embodiment, the oil-in-water emulsion contains less than about 5% short chain alcohol having 5 carbon atoms in the carbon chain backbone. In another embodiment the oily composition further contains a foaming aid.n n n In one or more embodiments, the oil-in-water emulsion contains hydrophobic solvent and water in a weight ratio of about 1: 3 to 6: 1.n n n In at least one embodiment, the oil-in-water emulsion comprises a hydrophobic solvent having a solubility of at least about 1 gram per 100 mL in distilled water at ambient temperature. Hydrophobic solvents may be selected from mineral oils, MCT oils, triglyceride oils, silicone oils, polyunsaturated oils, unsaturated oils and essential oils.n n n Oil-in-water emulsions may comprise a strong solvent selected from the group comprising hydrophobic solvents, co-solvents and emollients which are not mineral oils. Here, the strong solvent solubilizes more fully than the mineral oil solubilizes the active agent. For example, mineral oil solubilizes at least five or ten times better than solubilizing the active agent.n n n In at least one embodiment, the oil-in-water emulsion comprises a surfactant having an HLB value in the range of about 3 to 10 to promote the formation of an oil-in-water emulsion.n n n In at least one embodiment, the oil-in-water emulsion is at least one selected from the group comprising natural polymeric materials, semi-synthetic polymeric materials, synthetic polymeric materials, inorganic gelling agents and mixtures thereof The above gelling agent is included. However, in further embodiments, no gelling agent is necessary.n n n The active agent may be a therapeutic or cosmetic solution. Therapeutic agents are selected for the prevention or treatment of skin, mucous membranes, ear channels, vagina, penis urethra and rectal disorders. In one or more embodiments the therapeutic agent is an anti-infection, antibiotic, antibacterial, antifungal, antiviral, antiparasitic, anti-inflammatory, anesthetic, analgesic, anti-allergic, corticosteroid, retinoid, antiproliferative agent, anticancer agent, Photodynamic therapeutic agents, lubricants and mixtures thereof.n n n Alternatively, the active agent is an inorganic solid material, preferably metal oxide, more preferably titanium oxide and zinc oxide.n n n The active agent may also be a cosmetic preparation such as a retinoid, an anti-wrinkle agent, a radical scavenger, an auto tanning agent, a skin whitening agent, a skin protectant, an anticellulite agent, a massage oil, an anti wart agent.n n n In another aspect, the present invention provides for the treatment or alleviation of a dermatological or mucosal disease or disorder by topically applying a therapeutically effective amount of an oil-in-water emulsion or oily composition of the present invention to a subject having a disease or disorder. Or provide a method of prevention.n n n However, in another aspect, the present invention also provides a method of designing a foaming composition containing at least one active agent that is not sufficiently soluble in a hydrocarbon solvent containing mineral oil. The method includes selecting at least one active agent and identifying the solvent that solubilizes the active agent more sufficiently than the mineral oil solubilizes the active agent. The method further includes adjusting the concentration and type of surfactant and gelling agent to provide a foamable composition.n n n In at least one embodiment, the strong solvent solubilizes the active agent five or ten times better than the mineral oil solubilizes the active agent.n n n Skin, mucous, oily foam-forming composition |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3881829-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101722924-B1 |
| priorityDate | 2003-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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