| abstract |
It is an object of the present invention to provide for diseases involving CRF, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, gastrointestinal disease, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, head trauma, inflammation, To provide an antagonist to the CRF receptor and / or an agonist for the δ-receptor effective as a therapeutic or prophylactic agent for immune-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitis, schizophrenia, pain and the like.n n n Pyrrolopyrimidine or pyrrolopyridine derivatives substituted with cyclic amino groups of the general formula (I) have high affinity for the CRF receptor and / or the δ receptor and are effective in diseases in which CRF is believed to be involved.n n n <Formula I> |