| abstract |
The present invention relates to gamma-secretase inhibitors of Formula (I) useful for treating a variety of neurodegenerative diseases.n n n Formula In n n n n n n n In Formula I,n n n R 1 is unsubstituted or comprises a substituted aryl or heteroaryl group;n n n R 2 is —C (O) —Y, alkylene-C (O) —Y, alkylene-cycloalkylene-C (O) —Y, cycloalkylene-alkylene-C (O) —Y, alkyl Ylenecycloalkylene-alkylene-C (O) -Y, cycloalkylene-C (O) -Y, -S (O) -Y, alkylene-S (O) -Y, alkylene-cycloalkylene -S (O) -Y, cycloalkylene-alkylene-S (O) -Y, alkylene cycloalkylene-alkylene-S (O) -Y, cycloalkylene-S (O)- Y ,, -S (O 2 ) -Y, alkylene-S (O 2 ) -Y, alkylene cycloalkylene -S (O 2 ) -Y, cycloalkylene alkylene-S (O 2 ) -Y , Alkylene cycloalkylene-alkylene-S (O 2 ) -Y and cycloalkylene-S (O 2 ) -Y, alkylene cycloalkylene-alkylene-S (O 2 ) -Y and cycloalkylene -S (O 2 ) -Y, wherein Y is as defined in the specification, and each of said alkylene or cycloalkylene may be unsubstituted or substituted as defined herein;n n n Each R 3 comprises H, alkyl, Oalkyl, OH, N (R 9 ) 2 , acyl and aroyl; Or residue (R 3 ) 2 defines a carbonyl group, —C (O), with a ring carbon atom where they are shown attached to formula (I);n n n Each R 3A and R 3B independently comprises H or alkyl;n n n R 11 independently includes aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl or alkoxyalkyl.n n n One or more compounds of formula (I), or pharmaceutically acceptable salts, solvates and / or compositions thereof, may be used to treat, for example, Alzheimer's disease. |