| abstract |
Compounds with limited conformation have been described, similar to the secondary structure of the reverse-turn sites of biologically active peptides and proteins. Such reverse-turn analogs are useful in a wide range of fields, including use as diagnostic and prophylactic agents. Libraries comprising reverse-turn analogs of the present invention have also been described, and methods of screening the library for identifying biologically active members have also been described. The present invention also relates to compounds that are regulated by the Wnt-signaling pathway, ie cancers, in particular colorectal cancer, restenosis associated with angioplasty, polycystic disease, abnormal angiogenesis, rheumatoid arthritis, Nodules sclerotic syndrome, hair growth, ulcerative colitis, the use of inhibiting or treating. |