| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-127 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C243-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-42 |
| filingDate |
2005-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_302d9feb2fc8840bb1ef36528415b889
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc8f87d526c3e7eeb0a5f09f64e48df5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77bb4eac547a9ea554302544d53d9ed1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9cc00a8d75fac400cc6697576a961f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2160683a685e0016f910b6cf1d37135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56d48000826a57b0aa145506334effe9 |
| publicationDate |
2007-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20070006935-A |
| titleOfInvention |
Atazanavir bisulfate and methods of preparation of new forms |
| abstract |
The present invention reacts a solution of atazanavir free base with concentrated sulfuric acid in an amount reacting with less than about 15% by weight of atazanavir free base, and forms A of atazanavir bisulfate as a crystal in the form of atazanavir bisulfate. Seeds of crystals are added to the reaction mixture and additional concentrated sulfuric acid is added in multistep at increasing rates according to the cubic equation to form Form A crystals of atazanavir bisulfate, HIV protease inhibitor atazanavir bisulfate It relates to a method of manufacturing. The present invention also relates to a process for preparing atazanavir bisulfate as a pattern C material. The present invention also relates to a novel form of atazanavir bisulfate in form E3, which is a highly crystalline triethanolate solvate of bisulfate salts from ethanol. |
| priorityDate |
2004-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |