| abstract |
The compounds of formula (I) and their esters may be administered transdermally. It is preferably applied as a patch with an adhesive comprising a copolymer of 40 to 60% by weight methoxyethyl acrylate, 30 to 40% by weight lauryl acrylate or lauryl methacrylate and 10 to 25% by weight polar monomer. When it is especially effective.n n n [Formula I]n n n n n n n n (Wherein R 1 , R 2 , R 3 and R 4 are the same or different from each other and each represents an oxo group, a hydroxy group, a mercapto group, a hydrogen atom, a halogen atom, an alkoxy group or an aryloxy group; Indicates that there may be a single bond or a double bond between each pair of nonadjacent carbon atoms of 1 or 2) |