| abstract |
Compounds of formula (I) or pharmaceutically acceptable salts thereof are described.n n n [Formula I]n n n n n n n n In Formula I,n n n R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl;n n n R 1 , R 2 , R 3 , R 4 and R 5 are H, alkyl or alkoxyalkyl;n n n Z is optionally substituted aryl or heteroaryl.n n n Also described are the use of the compounds of formula (I) in treating central nervous system diseases, particularly Parkinson's disease, and pharmaceutical compositions comprising them, either alone or in combination with other agents for treating Parkinson's disease. |